GenomicseLifePeer-reviewed
Activity-based CRISPR Scanning Uncovers Allostery in DNA Methylation Maintenance Machinery
Kevin Chun-Ho Ngan, Samuel M. Hoenig, Hui Si Kwok…·Brian B. Liau
This study uses activity-based CRISPR scanning to identify allosteric sites in DNMT1 and UHRF1, revealing gain-of-function mutations that enhance DNA methylation activity.
16 citations