Author

Samuel M. Hoenig

Broad InstituteORCID 0000-0003-0067-4729Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:perturbation response prediction· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Brian B. LiauiD· 2 shared Kevin Chun-Ho NganiD· 2 shared Nicholas Z. LueiD· 2 shared Pallavi M. GosaviiD· 2 shared Ceejay LeeiD· 1 shared Cindy SuiD· 1 shared David A. TanneriD· 1 shared Emma M GarciaiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

Brian B. LiauORCID

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2 papers

Recent·Most cited

GenomicseLifePeer-reviewedFeb 10, 2023

Activity-based CRISPR Scanning Uncovers Allostery in DNA Methylation Maintenance Machinery

Kevin Chun-Ho Ngan, Samuel M. Hoenig, Hui Si Kwok…·Brian B. Liau

This study uses activity-based CRISPR scanning to identify allosteric sites in DNMT1 and UHRF1, revealing gain-of-function mutations that enhance DNA methylation activity.

16 citations

humanCRISPR screen

𝕏 PostBluesky

Molecular BiologyACS Central SciencePeer-reviewedFeb 14, 2022

Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders

Pallavi M. Gosavi, Kevin Chun-Ho Ngan, Megan J. R. Yeo…·Brian B. Liau

This study identifies drug resistance mutations in neosubstrates of molecular glue degraders using CRISPR-suppressor scanning and reveals common resistance mechanisms.

56 citationstop 5%

humanCRISPR screen

𝕏 PostBluesky