Paul S. Maddox

Multiscale temporal tuning of force generation complex machinery governs cortical microtubule interactions during the first mitotic division in C. elegans

The paper investigates the regulation of cortical dynein and its interaction with microtubules during mitosis in C. elegans by analyzing the effects of depleting complex components and regulators.

Coordinated chromosome motion emerges from mechanical coupling mediated by the physical spindle environment

This study identifies the mechanical basis of coordinated chromosome motion during metaphase using live-cell imaging, perturbations, and a minimal mechanical model.

Subcellular context-specific tuning of actomyosin ring contractility within a common cytoplasm

The paper investigates how actomyosin rings generate contractile force in different cellular contexts using a physical model to show that component abundance and distribution tune force magnitude while preserving conserved mechanics.

POT-1 telomere binding protein promotes a novel form of Transgenerational Epigenetic Inheritance

This study shows that C. elegans POT-1 proteins regulate telomeric foci in gametes across generations without affecting telomere length.

Embryo timelapses can be compiled and quantified to understand canonical histone dynamics across multiple cell cycles.

The paper quantifies histone dynamics in early C. elegans embryos using a streamlined pipeline and fluorescent labeling.

Nucleo-cytoplasmic trafficking regulates nuclear surface area during nuclear organogenesis

The paper develops a model showing that nucleo-cytoplasmic trafficking regulates nuclear surface area during nuclear organogenesis, supported by experiments in mammalian and Drosophila systems.