Kerry Bloom

This study identifies the mechanical basis of coordinated chromosome motion during metaphase using live-cell imaging, perturbations, and a minimal mechanical model.

This paper shows that expressing HP1 homologues in yeast increases chromatin compaction, reducing mutation and recombination rates, and improving the stability of synthetic metabolic circuits.

The paper identifies tardigrade mitochondrial single-stranded DNA-binding proteins as effective desiccation protectants through a bacterial expression cloning screen.

The paper investigates how transient crosslinking kinetics in budding yeast nucleolus affect gene cluster dynamics, finding an optimal crosslink lifetime that maximizes gene interactions.

This study shows that removing tRNA genes from a chromosome does not broadly disrupt chromosome folding but affects local nucleosome positioning and SMC protein binding, as well as centromere and heterochromatin clustering.