Yanli Wang

This study reveals the structure of a hexameric phosphatase holoenzyme formed by a pathogen effector and host enzyme, showing enhanced stability and virulence function.

The paper develops a custom ENCODE annotation for cancer genomics, highlighting TF-RBP interactions and network rewiring during oncogenesis, and validates findings using experimental assays.

The paper designs improved anti-CRISPR proteins with enhanced inhibition potency and expanded specificity through structure-based engineering.

The paper introduces a web-based browser for visualizing 3D genome organization and chromatin interactions, enabling integration with other omics data to study gene regulation.

This paper presents an integrative framework to detect structural variants in cancer genomes using multiple methods and finds that non-coding structural variation significantly impacts genome function in cancer cells.