Author

David D. Eisenstat

Royal Children's HospitalORCID 0000-0002-5976-0798Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1 Organism:zebrafish· 1

Frequent Co-Authors

Maree C. FauxiD· 2 shared Mirana RamialisoniD· 2 shared Natalie CharitakisiD· 2 shared Ryan F. LeungiD· 2 shared Alexander MaytumiD· 1 shared Andrew G. ElefantyiD· 1 shared Ankita M. George· 1 shared Anna L. LeichteriD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersDevelopmental Biology

Maree C. FauxORCID

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3 papers

Recent·Most cited

The DLX/Notch axis is necessary for spatiotemporal regulation of neural cell fate

Ryan F. Leung, Michael See, Ankita M. George, Patrick L. Barry, Kyle France, Natalie Charitakis, Mirana Ramialison, Maree C. Faux, David D. Eisenstat

The paper identifies a DLX2-regulated gene network that represses Notch signaling and glial fate factors to control neuronal-glial cell fate during forebrain development.

Nature Communications · Aug 20, 2026Peer-reviewedDevelopmental Biology

Application of spatial transcriptomics across organoids: a high-resolution spatial whole-transcriptome benchmarking dataset

Maria Rosaria Nucera, Natalie Charitakis, Ryan F. Leung, Anna L. Leichter, Natasha Tuano, Marzena Walkiewicz, Vallari Sawant, Lynn Rowley, Michelle Scurr, Pei Xuan Er, Ker S. Tan, Rebecca Sutton, Feroz Ahmad, Ritika Saxena, Alexander Maytum, , Mirana Ramialison

This paper benchmarks spatial transcriptomics in stem cell-derived organoids using Stereo-seq, optimizing RNA capture and introducing regional analysis methods.

iScience · Apr 21, 2026Peer-reviewedBioinformatics

Distal-less genes Dlx1/Dlx2 repress oligodendrocyte genesis through transcriptional inhibition of Olig2 expression in the developing vertebrate forebrain

Qiang Jiang, Jamie L. Zagozewski, Roseline Godbout, David D. Eisenstat

bioRxiv · Apr 9, 2020 · PreprintDevelopmental Biology