Pei Xuan Er

Application of spatial transcriptomics across organoids: a high-resolution spatial whole-transcriptome benchmarking dataset

This paper benchmarks spatial transcriptomics in stem cell-derived organoids using Stereo-seq, optimizing RNA capture and introducing regional analysis methods.

In vitro plasticity between ureteric epithelial and distal nephron identity and maturity is controlled by extracellular signals.

This study shows that hPSC-derived distal nephron epithelium can adopt ureteric or nephric duct-like identities in vitro in response to extracellular signals.

Nephron segmentation and patterning in kidney organoids can be modulated by distinct FGF subfamily members

This study shows that distinct FGF subfamily members modulate nephron patterning in kidney organoids, with FGF8b and FGF10 having unique effects on proximal and distal nephron development.

High throughput single cell RNA-seq of developing mouse kidney and human kidney organoids reveals a roadmap for recreating the kidney

The paper uses single-cell RNA-seq to analyze developing mouse kidney and human kidney organoids, identifying cell clusters and revealing insights into kidney development and organoid maturation.

Transcriptional evaluation of the developmental accuracy, reproducibility and robustness of kidney organoids derived from human pluripotent stem cells