ImmunologyImmunityPeer-reviewed
P2RY2 is a purinergic immune checkpoint linking extracellular ATP to immune evasion and adaptive resistance to immunotherapy
Zhaoqing Hu, Hitoshi Matsuo, Shangce Du…·Chong Sun
This paper identifies P2RY2 as a purinergic immune checkpoint that mediates eATP-driven immune evasion and adaptive resistance to immunotherapy by promoting PGE2 accumulation in the tumor microenvironment.
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