Author

Helena Engel

German Cancer Research CenterORCID 0000-0001-9792-7694Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Beiping MiaoiD· 2 shared Chong SuniD· 2 shared Shangce DuiD· 2 shared Alexander KowariD· 1 shared Ali Hyder Baig· 1 shared Cansu Eris· 1 shared Catarina PechinchaiD· 1 shared Cecilia Berzain Battioni· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Beiping MiaoORCID

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2 papers

Recent·Most cited

P2RY2 is a purinergic immune checkpoint linking extracellular ATP to immune evasion and adaptive resistance to immunotherapy

Zhaoqing Hu, Hitoshi Matsuo, Shangce Du, Cecilia Berzain Battioni, Lena Jassowicz, Rafael Carretero, Melanie Sator‐Schmitt, Xiyue Zhao, Beiping Miao, Cansu Eris, Helena Engel, Mohamed A.A. Mahmoud, Elke Laport, Yanling Xiao, Ilse Hofmann, , Chong Sun

This paper identifies P2RY2 as a purinergic immune checkpoint that mediates eATP-driven immune evasion and adaptive resistance to immunotherapy by promoting PGE2 accumulation in the tumor microenvironment.

Immunity · Jul 1, 2026Peer-reviewedImmunology

Dual Ribosome Profiling reveals metabolic limitations of cancer and stromal cells in thetumor microenvironment

Daniela Avilés Huerta, Rossella Del Pizzo, Alexander Kowar, Ali Hyder Baig, Giuliana Palazzo, Ekaterina Stepanova, Cinthia Claudia Amaya Ramirez, Sara D’Agostino, Edoardo Ratto, Catarina Pechincha, Nora S. Siefert, Helena Engel, Shangce Du, Silvia Cadenas-De Miguel, Beiping Miao, , Fabricio Loayza‐Puch

This study uses Dual Ribosome Profiling to reveal cell type-specific metabolic limitations in the tumor microenvironment, showing how amino acid availability affects immunotherapy outcomes.

Nature Communications · May 19, 2025Peer-reviewedCancer Biology