P2RY2 is a purinergic immune checkpoint linking extracellular ATP to immune evasion and adaptive resistance to immunotherapy
Zhaoqing Hu, Hitoshi Matsuo, Shangce Du, Cecilia Berzain Battioni, Lena Jassowicz, Rafael Carretero, Melanie Sator‐Schmitt, Xiyue Zhao, Beiping Miao, Cansu Eris, Helena Engel, Mohamed A.A. Mahmoud, Elke Laport, Yanling Xiao, Ilse Hofmann, , Chong Sun
This paper identifies P2RY2 as a purinergic immune checkpoint that mediates eATP-driven immune evasion and adaptive resistance to immunotherapy by promoting PGE2 accumulation in the tumor microenvironment.
Immunity · Jul 1, 2026Peer-reviewedImmunology