Cancer BiologybioRxivPreprint
Platelet-Mediated Suppression of T Cell Function Drives Immune Evasion in Triple Negative Breast Cancer through the P-Selectin / PSGL-1 Pathway
Margaret R. Smith-Oliver, Deepa Gautam, Emily M. Clarke…·Elisabeth M. Battinelli
This paper identifies a platelet-mediated immune evasion mechanism in TNBC via the P-selectin/PSGL-1 pathway, showing that blocking P-selectin can restore T-cell function and improve ICI response.
DOI 10.1101/2025.09.12.675650