Bruce Evan Johnson

This study analyzes genomic alterations in a large IBC cohort, finding high TP53 mutation frequency and NOTCH pathway enrichment, but no major genomic differences compared to non-IBC cases.

This paper evaluates computational methods to infer germline vs. somatic variants from tumor-only sequencing data using 1,608 patients and compares results to germline testing.

The paper uses Perturb-CITE-Seq to identify novel immune evasion mechanisms in cancer by analyzing multi-modal single-cell data from patient-derived models.

ExSeq enables multiplexed RNA mapping at nanoscale resolution by expanding biological specimens for in situ sequencing.

The paper develops a toolbox for scRNA-Seq and snRNA-Seq of fresh and frozen human tumors, testing it across eight tumor types and optimizing protocols for different tissue characteristics.

MatchMiner automates matching cancer patients to precision medicine trials using genomic and clinical criteria, enabling efficient and accurate trial enrollment.