Tara A. LeGates

Alcohol disrupts long-term potentiation at hippocampus-medium spiny neuron synapses in the medial shell of the nucleus accumbens

This study shows that ethanol disrupts long-term potentiation at hippocampus-medium spiny neuron synapses in the nucleus accumbens, with effects persisting during early abstinence.

GABAB Receptors Gate Sex-Specific Synaptic Plasticity in the Nucleus Accumbens

This study shows that GABAB receptor inhibition converts LTP to LTD selectively in female mice at Hipp-NAc synapses, revealing a sex-specific role in synaptic plasticity regulation.

Physical restraint induces conditioned place aversion and region-specific c-Fos activation in mice

This study shows that physical restraint in mice leads to conditioned place aversion and region-specific c-Fos activation in brain areas related to aversion and context.

Heterosynaptic interactions between dorsal and ventral hippocampus in individual medium spiny neurons of the nucleus accumbens ventromedial shell

The paper investigates anatomical and functional convergence of dorsal and ventral hippocampal inputs in the nucleus accumbens, revealing heterosynaptic interactions between these pathways in individual neurons.

Sex-specific mechanisms underlie long-term potentiation at hippocampus-nucleus accumbens synapses

The paper investigates sex differences in the molecular mechanisms underlying long-term potentiation (LTP) at hippocampus-nucleus accumbens synapses, finding sex-specific requirements for Ca2+ influx and estrogen receptor activity.

Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength

This study shows that LRRTM2 controls AMPAR subsynaptic positioning, which dynamically regulates synaptic strength by affecting receptor clustering near presynaptic release sites.