Thomas Biederer

This paper introduces pan-ExM-t, an all-optical method for visualizing specific proteins in the ultrastructural context of brain tissue, demonstrating its application on various markers in mouse brain sections and neuron cultures.

The paper identifies a complex of TMEM24 and C2CD2 with band 4.1 proteins at ER/PM junctions, showing their role in lipid transport and cell-cell contact regulation.

This study identifies excitatory synapses as primary targets of α-synuclein aggregation in a Parkinson's disease mouse model, revealing spatial and temporal patterns of synaptic vulnerability.

This study shows that early adversity impairs microglial function in male mice, causing synaptic and behavioral deficits, while females show resilience through astrocytic compensation.

The paper identifies hub synapses in the mouse striatum formed by dopaminergic inputs that connect with glutamatergic, GABAergic, and cholinergic synapses, revealing a new framework for studying neuromodulation.

This study shows that LRRTM2 controls AMPAR subsynaptic positioning, which dynamically regulates synaptic strength by affecting receptor clustering near presynaptic release sites.

The paper shows SynCAM 1, regulated by visual experience, controls thalamic input onto PV+ interneurons, limiting cortical plasticity and closing the critical period.