Julia Ganz

Optimized chemogenetic ablation and regeneration of enteric nervous system neurons in zebrafish

This study develops a chemogenetic ablation model in zebrafish to study ENS neuron regeneration, showing complete restoration of most neuron subtypes but partial recovery of serotonergic neurons.

Linking Genetic Risk to Disease-Relevant Cellular States via Metacell-Informed Modeling with ICePop

ICePop links genetic risk to disease-relevant cellular states by analyzing single-cell transcriptomics data across multiple traits, identifying 1,684 disease-cell type associations.

A rapid F0 CRISPR screen in zebrafish to identify regulators of neuronal development in the enteric nervous system

This paper develops a rapid F0 CRISPR screen in zebrafish to identify genes regulating ENS neuronal development and finds five transcription factors that influence ENS neuron differentiation.

Evolution of Endothelin signaling and diversification of adult pigment pattern in Danio fishes

The paper identifies Endothelin-3 as a factor contributing to differences in iridophore development and pigment patterns between Danio rerio and D. nigrofasciatus.

Epigenetic factors coordinate intestinal development

This paper shows DNA methylation factors are crucial for intestinal development across multiple cell types, including neurons and smooth muscle, and identifies them as potential Hirschsprung disease candidates.

Image velocimetry and spectral analysis enable quantitative characterization of larval zebrafish gut motility

The paper introduces an image analysis technique using image velocimetry and spectral analysis to quantify gut contraction strength, frequency, and wave speed in larval zebrafish.

Host Gut Motility and Bacterial Competition Drive Instability in a Model Intestinal Microbiota

This study shows that host gut motility and bacterial competition together drive instability in a two-species intestinal microbiota, with reduced motility allowing coexistence.