Author

Simon Jurt

University of ZurichORCID 0000-0002-6016-8505Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Adriano AguzziiD· 1 shared Anna HenziiD· 1 shared Assunta SenatoreiD· 1 shared Asvin KK LakkarajuiD· 1 shared Caihong ZhuiD· 1 shared Federica Mazzola· 1 shared Georg MeisliD· 1 shared Giuliano SiligardiiD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Adriano AguzziORCID

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1 paper

Recent·Most cited

Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedAug 1, 2022

A conformational switch controlling the toxicity of the prion protein

Karl Frontzek, Marco Bardelli, Assunta Senatore…·Adriano Aguzzi

This study identifies an H-latch conformational switch in PrPC that drives prion toxicity and shows that disrupting this switch can protect against prion-related neurodegeneration.

35 citations

mouseprotein structure

𝕏 PostBluesky