Author

Tomáš Deingruber

University of CambridgeORCID 0000-0002-6017-9490Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Beata K. Blaszczyk· 1 shared David R. SpringiD· 1 shared Francisco Javier Pérez-ArealesiD· 1 shared James Mark WagstaffiD· 1 shared Marko HyvöneniD· 1 shared Matthew G. Sanders· 1 shared P. BreariD· 1 shared Radu Costin Bizga NicolescuiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Beata K. Blaszczyk

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1 paper

Recent·Most cited

Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Cova-lent Binder

Rebekah M. West, Radu Costin Bizga Nicolescu, P. Brear, James Mark Wagstaff, Beata K. Blaszczyk, Tomáš Deingruber, Matthew G. Sanders, Francisco Javier Pérez-Areales, David R. Spring, Marko Hyvönen

The paper identifies a covalent binder targeting a lysine in the PIP3 binding site of BTK's PH domain, offering a novel approach to inhibit BTK beyond traditional ATP site targeting.

Journal of Medicinal Chemistry · May 14, 2026Peer-reviewedBiochemistry