James Mark Wagstaff

Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Cova-lent Binder

The paper identifies a covalent binder targeting a lysine in the PIP3 binding site of BTK's PH domain, offering a novel approach to inhibit BTK beyond traditional ATP site targeting.

Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle(R)) Antimicrobial Inhibitor of Escherichia coli PBP3

This study discovers and optimizes bicyclic peptide inhibitors of E. coli PBP3, showing high-affinity binding and broad-spectrum antimicrobial activity.

Cytomotive actins and tubulins share a polymerisation switch mechanism conferring robust dynamics

The paper identifies a shared polymerisation switch mechanism in cytomotive actins and tubulins that ensures filament stability and functional dynamics.

Cryo-EM structure of the MinCD copolymeric filament from Pseudomonas aeruginosa at 3.1 A resolution

The paper reports the high-resolution cryo-EM structure of Pseudomonas aeruginosa MinCD copolymeric filaments, revealing their composition and membrane interaction.