Marko Hyvönen

The paper identifies two protein contaminants from affinity-purified samples using cryo-EM and mass spectrometry, emphasizing the importance of resin specificity in purification.

The paper identifies a covalent binder targeting a lysine in the PIP3 binding site of BTK's PH domain, offering a novel approach to inhibit BTK beyond traditional ATP site targeting.

This study shows anti-activin treatment reduces desmoplastic barriers and increases T cell infiltration in tumors, improving survival in SMAD4-null pancreatic cancer models.

The paper identifies a drug combination targeting human POMC neurons to reduce food intake and body weight using hPSC-derived neurons and mouse models.

This paper introduces a method to evolve protease activity and specificity using yeast display and alpha-2-macroglobulin-mediated covalent capture, demonstrating its application on six serine proteases.

The study shows that the H202D variant in GDF-15 does not affect its bioactivity but causes underreporting in R&D immunoassays, with correction equations provided.