Author

Lin Sen Cao

The University of Texas at San Antonio Health Science CenterORCID 0000-0002-6030-8619Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

Boon Seng Kho· 1 shared Chengyuan Yue· 1 shared Daohong ZhouiD· 1 shared Fangcheng Yu· 1 shared Frederic J. KayeiD· 1 shared Guangrong ZhengiD· 1 shared Hao LiuiD· 1 shared Janet S. Wiegand· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

Boon Seng Kho

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2 papers

Recent·Most cited

Pharmacology & ToxicologyComputational and Structural Biotechnology JournalPeer-reviewedJan 1, 2025

HerbComb: an integrated database for the discovery of novel combinational therapies from herbal medicines

Yinyin Wang, Rui Liu, Xiangrong Luo…·Jing Ping Tang

HerbComb is a database that identifies synergistic herbal medicine combinations by analyzing gene signatures and pharmacological properties, validated using Tongxinluo for Stroke.

6 citations

proteomicsmetagenomics

𝕏 PostBluesky

Cancer BiologyCellsPeer-reviewedMar 17, 2024

PROTAC-mediated dual degradation of BCL-xL and BCL-2 is a highly effective therapeutic strategy in small-cell lung cancer

Sajid Ullah Khan, Lin Sen Cao, Janet S. Wiegand…·Daohong Zhou

This paper evaluates a dual BCL-xL/BCL-2 degrader, 753b, showing it effectively reduces tumor viability and growth in SCLC models while avoiding platelet toxicity seen with navitoclax.

43 citationstop 3%

mouseexperimental assay

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