Author

Philip M. Brown

The University of Texas Southwestern Medical CenterORCID 0000-0002-6040-8812Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Kimberly A. ReynoldsiD· 2 shared Agata Turska-NowakiD· 1 shared Christine IngleiD· 1 shared Dhiraj DokwaliD· 1 shared Ryan M. OttoiD· 1 shared Scott H. SaundersiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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2 shared papersSynthetic Biology

Kimberly A. ReynoldsORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintApr 10, 2026

Systematic CRISPRi screening reveals genetic modulators of E. coli isoprenoid production

Dhiraj Dokwal, Philip M. Brown, Christine Ingle…·Kimberly A. Reynolds

This study uses CRISPRi screening to identify E. coli genes affecting lycopene production, finding 31 genes that significantly modify yield across various metabolic pathways.

DOI 10.64898/2026.04.10.717724

E. coliexperimental assay

𝕏 PostBluesky

Systems BiologyCell SystemsPeer-reviewedFeb 1, 2024

A continuous epistasis model for predicting growth rate given combinatorial variation in gene expression and environment

Ryan M. Otto, Agata Turska-Nowak, Philip M. Brown, Kimberly A. Reynolds

The paper develops a continuous epistasis model to predict E. coli growth rate based on gene expression and environmental variations using experimental data.

17 citations

E. colibulk RNA-seq

𝕏 PostBluesky