Author

Christine Ingle

The University of Texas Southwestern Medical CenterORCID 0000-0002-0203-2845Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein design· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Kimberly A. ReynoldsiD· 2 shared Andrew D. MathisiD· 1 shared Andrew F. SchoberiD· 1 shared Dhiraj DokwaliD· 1 shared Ivan JunieriD· 1 shared Joshua D. RabinowitziD· 1 shared Junyoung O. ParkiD· 1 shared Li CheniD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersSynthetic Biology

Kimberly A. ReynoldsORCID

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2 papers

Recent·Most cited

Systematic CRISPRi screening reveals genetic modulators of E. coli isoprenoid production

Dhiraj Dokwal, Philip M. Brown, Christine Ingle, Scott H. Saunders, Kimberly A. Reynolds

This study uses CRISPRi screening to identify E. coli genes affecting lycopene production, finding 31 genes that significantly modify yield across various metabolic pathways.

bioRxiv · Apr 10, 2026 · PreprintSynthetic Biology

A two-enzyme adaptive unit in bacterial folate metabolism

Andrew F. Schober, Andrew D. Mathis, Christine Ingle, Junyoung O. Park, Li Chen, Joshua D. Rabinowitz, Ivan Junier, Olivier Rivoire, Kimberly A. Reynolds

The paper investigates adaptive dependencies between enzymes in bacterial folate metabolism, showing that DHFR and TYMS form a modular unit that can adapt independently from the rest of the genome.

Cell Reports · Jun 1, 2019Peer-reviewedSystems Biology