Kimberly A. Reynolds

This study shows that inserting a domain into a protein's sector-connected surface increases the likelihood of evolving allosteric regulation, while non-sector-connected sites are less evolvable.

This study uses CRISPRi screening to identify E. coli genes affecting lycopene production, finding 31 genes that significantly modify yield across various metabolic pathways.

This study investigates how domain insertion in a synthetic enzyme fusion enables light-induced allosteric regulation through localized conformational changes and bidirectional domain coupling.

The paper develops a continuous epistasis model to predict E. coli growth rate based on gene expression and environmental variations using experimental data.

The paper investigates adaptive dependencies between enzymes in bacterial folate metabolism, showing that DHFR and TYMS form a modular unit that can adapt independently from the rest of the genome.

The paper identifies and engineers phosphorylation sites on kinases to rewiring cell signaling through allosteric regulation.

This paper introduces statistical coupling analysis (SCA) to decompose proteins into functional sectors and presents new methods for sector analysis in a Python software package.