Author

Alexei Hernandez

Johns Hopkins UniversityORCID 0000-0002-6044-2631Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell-cell communication· 2 Assay:imaging· 2 Research Focus:spatial domain detection· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Jae Woo LeeiD· 3 shared Sarah M. ShiniD· 3 shared Won Jin HoiD· 3 shared Yeonju ChoiD· 3 shared Atul M. DeshpandeiD· 2 shared Elizabeth M. JaffeeiD· 2 shared Erin M. CoyneiD· 2 shared Andrew J. EwaldiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCancer Biology

Jae Woo LeeORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintJun 12, 2025

Modeling cellular influence delineates functionally relevant cellular neighborhoods in primary and metastatic pancreatic ductal adenocarcinoma.

Yeonju Cho, Jae Woo Lee, Sarah M. Shin…·Won Jin Ho

The paper introduces FunCN, a method to analyze cellular neighborhoods in PDAC, revealing distinct immune interactions in primary and metastatic sites.

1 citation

humanimaging

Cancer BiologybioRxivPreprintJan 7, 2025

Cancer associated fibroblasts drive epithelial to mesenchymal transition and classical to basal change in pancreatic ductal adenocarcinoma cells with loss of IL-8 expression

Samantha R. Guinn, Brayan Perez, Joseph A. Tandurella…·Jacquelyn W. Zimmerman

The paper investigates how cancer-associated fibroblasts (CAF) influence tumor cell behavior in pancreatic ductal adenocarcinoma by driving EMT and altering cell subtypes, with IL-8 playing a key modulatory role.

2 citations

humanbulk RNA-seq

Cancer BiologyOncogenePeer-reviewedAug 20, 2024

Mapping the breast tumor microenvironment: proximity analysis reveals spatial relationships between macrophage subtypes and metastasis-initiating cancer cells

Eloïse M. Grasset, Atul M. Deshpande, Jae Woo Lee…·Won Jin Ho

The paper uses spatial analysis to show metastasis-initiating cancer cells in breast tumors are closely associated with specific macrophage subtypes, suggesting these interactions promote metastasis.

17 citations

humanimaging