Author

Lachlan G. Staker

South Australian Health and Medical Research InstituteORCID 0000-0002-6058-5616Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Ashleigh GeigeriD· 1 shared Caleb LushingtoniD· 1 shared Chandran PfitzneriD· 1 shared Fatwa AdikusumaiD· 1 shared G.I. GodahewaiD· 1 shared Jayshen ArudkumariD· 1 shared Jesse G. KennedyiD· 1 shared Louise J. RobertsoniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Ashleigh GeigerORCID

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1 paper

Recent·Most cited

Molecular BiologyBMC GenomicsPeer-reviewedFeb 12, 2025

Enhancing gRNA Transcript levels by Reducing the Scaffold Poly-T Tract for Optimal SpCas9- and SaCas9-mediated Gene Editing

Yu Chinn Joshua Chey, Luke Gierus, Caleb Lushington…·Fatwa Adikusuma

This study shows that shortening the 4T poly-T tract in gRNA scaffolds improves transcript levels and editing efficiency, especially under low vector conditions, for both SpCas9 and SaCas9.

16 citationstop 4%

CRISPR screenexperimental assay

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