Irene Cózar‐Castellano

Primary cilia coordinate c-KIT signaling induced proliferation in alpha cells

The paper identifies primary cilia as a signaling platform for c-KIT in pancreatic alpha cells, showing that c-KIT signaling via SCF promotes proliferation and may contribute to hyperglucagonemia in obesity and diabetes.

Preimplantation factor (PIF) links embryo-derived signaling to maternal pancreatic β-cell adaptation through an ERα-dependent pathway

This study identifies PIF as an embryo-derived signal that regulates maternal β-cell adaptation during pregnancy, showing its role in β-cell proliferation and insulin secretion through an ERα-dependent pathway.