Christophe Broca

Sodium tungstate promotes vascularization to support beta cell replacement in diabetes

Sodium tungstate enhances vascularization and improves survival of transplanted insulin-producing cells in diabetes models by upregulating VEGFA and promoting endothelial cell function.

Preimplantation factor (PIF) links embryo-derived signaling to maternal pancreatic β-cell adaptation through an ERα-dependent pathway

This study identifies PIF as an embryo-derived signal that regulates maternal β-cell adaptation during pregnancy, showing its role in β-cell proliferation and insulin secretion through an ERα-dependent pathway.

Direct reprogramming of human fibroblasts into insulin-producing cells by transcription factors

This study shows that human fibroblasts can be directly reprogrammed into insulin-producing cells using a specific transcription factor cocktail.