Anat Hendelman

Panagram reveals pangenome architectures underlying trait variation in plants and animals

Alignment-free pan-k-mer profiles track minimap2 similarity (whole-chromosome r^2 0.959-0.968), profile 605 vertebrate genomes in about a day on 40 cores, and nominate trait-linked loci across plants and animals.

A deep-time landscape of plant cis-regulatory sequence evolution

Conservatory, an orthogroup-centric conserved noncoding sequence finder, catalogs 2.3 million unique CNSs across 314 plant genomes and reveals regulatory elements older than angiosperms and seed plants.

A neofunctionalized flowering antagonist created an evolutionary contingency that channeled Solanaceae adaptation

The paper shows a neofunctionalized gene in Solanaceae plants became a flowering antagonist, influencing adaptation across species and environments.

Cryptic variation fuels plant phenotypic change through hierarchical epistasis

The paper identifies cryptic genetic variants in tomato that drive phenotypic change through hierarchical epistasis in a gene regulatory network.

Antagonizing cis-regulatory elements of a conserved flowering gene mediate developmental robustness

The paper identifies conserved cis-regulatory elements of the UFO gene in tomato and Arabidopsis, showing their role in maintaining developmental robustness through precise temporal control of gene expression.

Solanum pan-genomics and pan-genetics reveal paralogs as contingencies in crop engineering

The paper uses pan-genomics and genome editing in Solanum to show that paralog diversification hinders genotype-phenotype predictability in crop domestication.