Author

Adar Yaacov

Hebrew University of JerusalemORCID 0000-0002-6106-2307Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Itamar SimoniD· 2 shared Oriya VardiiD· 2 shared Shai RosenbergiD· 2 shared Amnon KoreniD· 1 shared Avraham Greenberg· 1 shared Britny Blumenfeld· 1 shared Dashiell J. MasseyiD· 1 shared Sheera AdariD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersBioinformatics

Itamar SimonORCID

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2 papers

Recent·Most cited

BioinformaticsScientific ReportsPeer-reviewedAug 12, 2023

Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rate

Oriya Vardi, Adar Yaacov, Shai Rosenberg, Itamar Simon

The paper analyzes 2,787 tumors to show that replication timing and mutation rate association is influenced by both cell autonomous and non-autonomous processes, including DNA repair, chromatin structure, and immune cell interactions.

DOI 10.1038/s41598-023-39463-1

humanbulk RNA-seq

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GenomicsCancer ResearchPeer-reviewedOct 26, 2021

Cancer mutational processes vary in their association with replication timing and chromatin accessibility

Adar Yaacov, Oriya Vardi, Britny Blumenfeld…·Shai Rosenberg

The paper analyzes mutational signatures in tumors to determine their association with replication timing and chromatin accessibility, finding signature-specific associations and clinical relevance of SBS16 in liver cancer.

24 citations

humanwhole-genome sequencing

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