Dashiell J. Massey

Differentiating mechanism from outcome for ancestry-assortative mating in admixed human populations

This paper uses genomic simulations to show that multiple mate-choice models can produce similar ancestry correlations in spouses, highlighting challenges in interpreting such data.

Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem Cells

The paper examines DNA replication timing in iPSCs, finding that some exhibit delayed replication at heterochromatic regions, which persists through differentiation and may affect their quality.

Telomere-to-telomere human DNA replication timing profiles

This study reports telomere-to-telomere replication timing profiles in human using the T2T-CHM13 genome assembly, showing replication timing in centromeres and heterochromatin.

High-throughput analysis of single human cells reveals the complex nature of DNA replication timing control

The paper uses single-cell whole-genome sequencing to analyze DNA replication timing in human cells, revealing variability in replication initiation sites and subtypes.

Sequencing Micronuclei Reveals the Landscape of Chromosomal Instability

The paper develops MN-seq to sequence DNA in micronuclei, revealing factors contributing to chromosomal instability and introducing scMN-seq for single-cell analysis.

Cancer mutational processes vary in their association with replication timing and chromatin accessibility

The paper analyzes mutational signatures in tumors to determine their association with replication timing and chromatin accessibility, finding signature-specific associations and clinical relevance of SBS16 in liver cancer.