A double hit affecting the IKZF1-IKZF2 tandem in immune cells of schizophrenic patients regulate specific symptoms
Iván Ballasch, Laura López-Molina, Marcos Galán-Ganga, Anna Sancho‐Balsells, Irene Rodríguez-Navarro, Sara Borràs‐Pernas, M. Angeles Rabadán, Wanqi Chen, Carlota Pastó-Pellicer, Francesca Flotta, Joaquín Fernández‐Irigoyen, Enrique Santamaría, Ruth Aguilar, Carlota Dobaño, Natalia Egri, , Albert Giralt
The paper shows that reduced IKZF1 and IKZF2 in immune cells of schizophrenic patients leads to impaired neural circuits and schizophrenia-like symptoms in mice and human cell models.
bioRxiv · Sep 9, 2024 · PreprintNeuroscience