Burkhard König

This study designs and synthesizes six new photoswitchable unnatural amino acids (psUAAs) for enzyme engineering, showing enhanced interaction potential and diverse photochemical behaviors.

The paper demonstrates a new method for reversible enzyme regulation using dichromatic irradiation of azobenzene, showing a two-fold increase in catalytic activity for one enzyme variant.

This study introduces Glyght, a light-controlled GlyR ligand that selectively modulates glycinergic neurotransmission in vivo, offering new tools for studying inhibitory circuits and phototherapies.