Photocontrol of endogenous glycine receptors in vivo

Alexandre M. J. Gomila; Karin Rustler; Galyna Maleeva; Alba Nin‐Hill; Daniel Wutz; Antoni Bautista-Barrufet; Xavier Rovira; Miquel Bosch; Elvira Mukhametova; Elena O. Petukhova; Daria Ponomareva; Marat A. Mukhamedyarov; Franck Peiretti; Mercedes Alfonso‐Prieto; Carme Rovira; Burkhard König; Piotr D. Bregestovski; Pau Gorostiza

doi:10.1016/j.chembiol.2020.08.005

NeuroscienceCell chemical biologyAug 25, 2020

Peer-reviewed journal article

Photocontrol of endogenous glycine receptors in vivo

Alexandre M. J. Gomila iD, Karin Rustler iD, Galyna Maleeva iD, Alba Nin‐Hill iD, Daniel Wutz, Antoni Bautista-Barrufet iD, Xavier Rovira iD, Miquel Bosch iD, Elvira Mukhametova iD, Elena O. Petukhova iD, Daria Ponomareva iD, Marat A. Mukhamedyarov iD, Franck Peiretti iD, Mercedes Alfonso‐Prieto iD, Carme Rovira iD, Burkhard König iD, Piotr D. Bregestovski iD, Pau Gorostiza iD

Abstract

Glycine receptors (GlyRs) are indispensable to maintain excitatory/inhibitory balance in neuronal circuits controlling reflex and rhythmic motor behaviors. Here we have developed Glyght, the first GlyR ligand controlled with light. It is selective over other cys-loop receptors, active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understand inhibitory circuits in intact animals, and to develop drug-based phototherapies.

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