Giovanna Zamboni

This study shows iPSC-derived astrocytes from AD patients reflect key pathophysiological features, offering a new model for AD research and therapeutic screening.

The paper uses induced pluripotent stem cell-derived cortical neurons from early Alzheimer's patients to show that cellular vulnerability to amyloid-beta correlates with clinical vulnerability.

This study compares domain adaptation techniques to improve white matter hyperintensity segmentation across different MRI datasets, finding that unsupervised domain adversarial training performs best.

This paper proposes a triplanar ensemble U-Net model for WMH segmentation on MR images, achieving robust performance comparable to existing methods.

This paper harmonises white matter hyperintensity measurements across two neuroimaging datasets by standardising preprocessing and modelling demographic and physiological differences.

This paper improves the BIANCA tool for WMH segmentation by introducing a locally adaptive thresholding method, LOCATE, which significantly enhances segmentation performance compared to global thresholding.

This paper develops a Bayesian spline method to model the spatio-temporal distribution of white matter hyperintensities with respect to age and validates it on simulated and real datasets.