Author

Abderhman Abuhashem

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-6135-5679Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Anna‐Katerina HadjantonakisiD· 3 shared Alexandra G. ChivuiD· 2 shared Charles G. DankoiD· 2 shared Edward J. Rice· 2 shared Adam C. SiepeliD· 1 shared Alexander PolyzosiD· 1 shared Alexandra L. JoyneriD· 1 shared Andreas KloetgeniD· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersGenomics

Anna‐Katerina HadjantonakisORCID

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4 papers

Recent·Most cited

GenomicsNature GeneticsPeer-reviewedJul 10, 2023

RNA polymerase II and PARP1 shape enhancer-promoter contacts

Gilad Barshad, James J. Lewis, Alexandra G. Chivu…·Charles G. Danko

This study investigates enhancer-promoter contact architecture and communication, finding that RNA polymerase II and PARP1 activity stabilize these contacts.

119 citationstop 1%

humanChIP-seq

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Molecular BiologybioRxivApr 21, 2022

RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription

Abderhman Abuhashem, Alexandra G. Chivu, Yixin Zhao…·Anna‐Katerina Hadjantonakis

The paper shows that RNA Pol II pausing is essential for proper pluripotency transitions in mouse embryos by maintaining balance between gene expression states.

22 citations

mousebulk RNA-seq

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Developmental BiologyDevelopmental CellPeer-reviewedApr 1, 2022

Rapid and efficient adaptation of the dTAG system in mammalian development reveals stage specific requirements of NELF

Abderhman Abuhashem, Andrew S. Lee, Alexandra L. Joyner, Anna‐Katerina Hadjantonakis

The paper validates the dTAG system for in vivo protein degradation during mammalian development, showing its safety, efficiency, and stage-specific effects on NELFB function.

56 citationstop 4%

mouseexperimental assay

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Molecular BiologybioRxivPreprintJun 7, 2019

KLF4 is involved in the organization and regulation of pluripotency-associated 3D enhancer networks

Dafne Campigli Di Giammartino, Andreas Kloetgen, Alexander Polyzos…·Effie Apostolou

This study investigates the role of KLF4 in chromatin reorganization and 3D enhancer rewiring during reprogramming of mouse embryonic fibroblasts to pluripotent stem cells.

4 citations

mouseChIP-seq

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