Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample
Michel Satya Naslavsky, Cláudia Kimie Suemoto, Luciano Abreu Brito, Marília O. Scliar, Renata Eloah de Lucena Ferretti‐Rebustini, Roberta Diehl Rodriguez, Renata Elaine Paraízo Leite, Nathalia Matta Araujo, Víctor Borda, Eduardo Tarazona‐Santos, Wilson Jacob Filho, Carlos Augusto Pasqualucci, Ricardo Nitríni, Kristine S. Yaffe, Mayana Zatz, Lea T. Grinberg
The paper examines how global and local ancestry influence the association between APOE ε4 and Alzheimer's neuropathology and cognitive outcomes in an admixed Brazilian cohort.
Molecular Psychiatry · Sep 7, 2022Peer-reviewedGenetic & Genomic Medicine