Kristine S. Yaffe

This paper investigates sex differences in genetic liability to modifiable Alzheimer's disease risk factors using polygenic risk scores and Mendelian randomization, finding limited and inconsistent sex-specific associations.

This paper evaluates cross-ancestry polygenic risk scores (PRS) for Alzheimer's disease across multi-ethnic populations, finding improved predictive accuracy in non-European groups.

This paper constructs a genomic-informed dementia risk score combining genetic and clinical factors and finds that most memory clinic patients have at least one high-risk indicator, with higher burden linked to increased dementia risk.

This study examines how telomere length, epigenetic age, and mitochondrial DNA abundance interact in Alzheimer's Disease, finding that their combination affects grey-matter volume.

This study uses Mendelian randomization to examine causal relationships between sleep apnea and Alzheimer's disease, coronary artery disease, and stroke, finding significant causal effects for CAD and stroke but not AD.

The paper predicts cognitive performance from sleep EEG features in older men, finding that certain EEG patterns are associated with cognitive ability, though this association weakens after adjusting for demographic and health factors.

The paper examines how global and local ancestry influence the association between APOE ε4 and Alzheimer's neuropathology and cognitive outcomes in an admixed Brazilian cohort.

The paper identifies genetic variants associated with Alzheimer's disease and cardiovascular risk factors, showing lipid-related enrichment and pleiotropy beyond APOE.