Michel Satya Naslavsky

The paper examines APOE ε2's protective role in admixed Brazilian elderly populations, finding that local ancestry influences its effects on longevity and disease risk.

The paper evaluates HLA imputation accuracy in admixed populations using dimension reduction, finding that custom reference panels outperform standard ones for specific genetic models.

This study evaluates the transferability of a breast cancer polygenic risk score in two Brazilian admixed cohorts compared to UK Biobank data, finding inflated PRS distributions and equivalent predictive power in case-control comparisons.

The paper examines how global and local ancestry influence the association between APOE ε4 and Alzheimer's neuropathology and cognitive outcomes in an admixed Brazilian cohort.

This study presents a high-coverage whole-genome sequencing dataset of 1,171 admixed elderly Brazilians, identifying novel variants and demonstrating the utility of WGS for genomic and clinical research in underrepresented populations.

The paper identifies genetic variants associated with resistance to SARS-CoV-2 infection by analyzing discordant Brazilian couples.

The paper investigates genetic variation in 27 candidate genes and HLA alleles in 954 admixed Brazilian exomes, identifying common and rare variants potentially influencing SARS-CoV-2 infection and response.

The paper identifies a West African-associated regulatory variant with a strong female-specific effect on BMI and fat mass in Brazilian admixed populations.

The paper analyzes structural variation in the glycophorin gene cluster across 6466 genomes, identifies 15 known and 9 new variants, and links structural variants to recombination hotspots.