This study examines the differential degeneration of wake- and sleep-modulating neurons in Alzheimer's disease, finding significant loss of orexinergic neurons and relative preservation of MCHergic neurons.

bioRxiv · Mar 6, 2024 · PreprintNeuroscience

Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample

Michel Satya Naslavsky, Cláudia Kimie Suemoto, Luciano Abreu Brito, Marília O. Scliar, Renata Eloah de Lucena Ferretti‐Rebustini, Roberta Diehl Rodriguez, Renata Elaine Paraízo Leite, Nathalia Matta Araujo, Víctor Borda, Eduardo Tarazona‐Santos, Wilson Jacob Filho, Carlos Augusto Pasqualucci, Ricardo Nitríni, Kristine S. Yaffe, Mayana Zatz, Lea T. Grinberg

The paper examines how global and local ancestry influence the association between APOE ε4 and Alzheimer's neuropathology and cognitive outcomes in an admixed Brazilian cohort.

Molecular Psychiatry · Sep 7, 2022Peer-reviewedGenetic & Genomic Medicine

Molecular characterization of selectively vulnerable neurons in Alzheimer's Disease

Kun Leng, Emmy Li, Rana April Eser, Antonia M. H. Piergies, Rene V. Sit, Michelle Tan, Norma F Neff, Song Hua Li, Roberta Diehl Rodriguez, Cláudia Kimie Suemoto, Renata Elaine Paraízo Leite, Alexander J. Ehrenberg, Carlos Augusto Pasqualucci, William W. Seeley, Salvatore Spina, , Martin Kampmann

The paper identifies molecular signatures of selectively vulnerable neurons in Alzheimer's Disease using single-nucleus RNA sequencing and validates findings with neuropathological methods.

Nature Neuroscience · Jan 11, 2021Peer-reviewedNeuroscience