Author

A. Deweever

University of South AlabamaORCID 0000-0002-6168-0076Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Aishwarya PrakashiD· 1 shared Andrzej Wierzbicki· 1 shared Camryn Hall· 1 shared E. Alan Salter· 1 shared Ji Young Lee· 1 shared Joel AndrewsiD· 1 shared Madeline Stone· 1 shared Mark R. Swingle· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Aishwarya PrakashORCID

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1 paper

Recent·Most cited

PPM1B utilizes a trinuclear metal architecture for phosphatase activity

Reece P. Stevens, Viktoriya Solodushko, Andrzej Wierzbicki, Thomas C. Rich, Mikael F Alexeyev, Marlo K. Thompson, Madeline Stone, Camryn Hall, A. Deweever, Sarah Sayner, Troy Stevens, Joel Andrews, Aishwarya Prakash, Richard E. Honkanen, Ji Young Lee, , Mark R. Swingle

This study identifies a trinuclear metal center in PPM1B that facilitates phosphate hydrolysis through direct substrate coordination and water protonation, revealing a novel catalytic mechanism.

bioRxiv · Apr 27, 2026 · PreprintBiochemistry