Author

Mark R. Swingle

University of South Alabama

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Richard E. HonkaneniD· 3 shared A. DeweeveriD· 1 shared Abigail MayeriD· 1 shared Aishwarya PrakashiD· 1 shared Andrzej Wierzbicki· 1 shared Brian E. WadzinskiiD· 1 shared Camryn Hall· 1 shared E. Alan Salter· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiochemistry

Richard E. HonkanenORCID

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Author profile →

3 papers

Recent·Most cited

PPM1B utilizes a trinuclear metal architecture for phosphatase activity

Reece P. Stevens, Viktoriya Solodushko, Andrzej Wierzbicki, Thomas C. Rich, Mikael F Alexeyev, Marlo K. Thompson, Madeline Stone, Camryn Hall, A. Deweever, Sarah Sayner, Troy Stevens, Joel Andrews, Aishwarya Prakash, Richard E. Honkanen, Ji Young Lee, , Mark R. Swingle

This study identifies a trinuclear metal center in PPM1B that facilitates phosphate hydrolysis through direct substrate coordination and water protonation, revealing a novel catalytic mechanism.

bioRxiv · Apr 27, 2026 · PreprintBiochemistry

The role of liprin-α1 phosphorylation in its liquid-liquid phase separation: regulation by PPP2R5D/PP2A holoenzyme

Abigail Mayer, Rita Derua, Elijah Spahn, Iris Verbinnen, Yang Zhang, Brian E. Wadzinski, Mark R. Swingle, Richard E. Honkanen, Veerle Janssens, Houhui Xia

This study identifies PPP2R5D/PP2A holoenzyme as an inhibitor of liprin-1 liquid-liquid phase separation through regulation of phosphorylation sites.

bioRxiv · Jun 18, 2024 · PreprintNeuroscience

The phosphatase inhibitor LB-100 acts synergistically with the NPR2 agonist BMN-111 to improve bone growth

Leia C. Shuhaibar, Nabil Kaci, Jeremy R. Egbert, Léa Loisay, Giulia Vigone, Tracy F. Uliasz, Emilie Dambroise, Mark R. Swingle, Richard E. Honkanen, Laurinda A. Jaffe, Laurence Legeai‐Mallet

The paper shows that combining the phosphatase inhibitor LB-100 with the NPR2 agonist BMN-111 enhances bone growth in a mouse model of achondroplasia.

bioRxiv · Sep 10, 2020 · PreprintDevelopmental Biology