Author

Andrzej Wierzbicki

University of South Alabama

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:metabolomics· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

E. Alan Salter· 2 shared A. DeweeveriD· 1 shared Aishwarya PrakashiD· 1 shared Camryn Hall· 1 shared Clarisse Iradukunda· 1 shared Dilipkumar UrediiD· 1 shared Ji Young Lee· 1 shared Joel AndrewsiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

E. Alan Salter

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Author profile →

2 papers

Recent·Most cited

PPM1B utilizes a trinuclear metal architecture for phosphatase activity

Reece P. Stevens, Viktoriya Solodushko, Andrzej Wierzbicki, Thomas C. Rich, Mikael F Alexeyev, Marlo K. Thompson, Madeline Stone, Camryn Hall, A. Deweever, Sarah Sayner, Troy Stevens, Joel Andrews, Aishwarya Prakash, Richard E. Honkanen, Ji Young Lee, , Mark R. Swingle

This study identifies a trinuclear metal center in PPM1B that facilitates phosphate hydrolysis through direct substrate coordination and water protonation, revealing a novel catalytic mechanism.

bioRxiv · Apr 27, 2026 · PreprintBiochemistry

Suppression of ITPK1 and IPMK activities impairs mTORC1 signaling due to accelerated signal termination and prevents pancreatic β-cell metabolic adaptation to excess glucose

Clarisse Iradukunda, E. Alan Salter, Dilipkumar Uredi, Xiaodong Wang, Andrzej Wierzbicki, Lucia E. Rameh

This study shows that reducing ITPK1 and IPMK activities lowers IP5 levels, which shortens mTORC1 signaling and hinders β-cell metabolic adaptation to high glucose.

bioRxiv · Mar 7, 2026 · PreprintBiochemistry