Pharmacology & ToxicologyJournal of Medicinal ChemistryPeer-reviewed
RSPO2-based peptibodies conjugated with pyrrolobenzodiazepine dimer or camptothecin analogs demonstrate potent anti-tumor activity by targeting the three receptors LGR4/5/6 in colorectal cancer and neuroblastoma
Yukimatsu Toh, Jianghua Tu, Ling Wu…·Qingyun J. Liu
The paper develops RSPO2-based peptibody-drug conjugates that target LGR4/5/6 receptors, showing potent anti-tumor activity in colorectal cancer and neuroblastoma models.