Multimodal spatial transcriptomics determines repeat expansion, huntingtin aggregation, and selective cortical neuron loss in Huntington Disease
Sonia Vazquez‐Sanchez, Olatz Arnold-García, Carlos Chillón-Marinas, Roy Maimon, Jie Cui, Katelyn McNair, Yuanyi Dai, Norma Martínez Jiménez, Daniel D. Child, Leslie Michels Thompson, Jone López‐Erauskin, Bogdan Bintu, Don W. Cleveland
This paper develops a multimodal spatial transcriptomics approach to study CAG repeat expansion, huntingtin aggregation, and neuron loss in Huntington's Disease using human brain tissue.
Cell · Oct 1, 2026Peer-reviewedNeuroscience