Cell BiologybioRxivPreprint
Structural Basis of Asymmetric Class C GPCR activation and distinct Gq coupling induced by force stimulation
Jin-Hui Ding, Jiale Wang, Weifeng Zhang…·Jin‐Peng Sun
This paper reveals how mechanical force activates mGlu2 through a unique cis mechanism and induces distinct Gq coupling, providing structural insights and a chemical toolset for modulating mechanosensitive GPCRs.