Jiale Wang

This paper reveals how mechanical force activates mGlu2 through a unique cis mechanism and induces distinct Gq coupling, providing structural insights and a chemical toolset for modulating mechanosensitive GPCRs.

This study identifies mGlu2 as a mechanosensitive GPCR in vestibular hair cells essential for balance, distinct from its role in hearing.

This study reveals the structural mechanism of cholesterol sensing by LYCHOS, showing how cholesterol binding modulates its interaction with GATOR1 to activate mTORC1.

This study identifies and characterizes genes involved in betalain biosynthesis in Aspergillus sydowii H-1, showing their role in morphology, conidiogenesis, stress response, and pigment synthesis.