BiophysicsEuropean Journal of Medicinal ChemistryPeer-reviewed
Temperature vaulting: A method for screening selective, slow- and tight-binding inhibitors targeting kinases in their non-native state
Sora Suzuki, Koji Umezawa, Gaku Furuie…·Isao Kii
This paper introduces a method called 'temperature vaulting' to screen inhibitors targeting kinases in their non-native state, demonstrating its effectiveness with the inhibitor FINDY (1) against DYRK1A.