Koji Umezawa

The paper engineers a covalent linkage into a de novo enzyme, revealing that the modified protein rescues cells through upregulating siderophore biosynthesis rather than catalyzing iron release.

This paper introduces a method called 'temperature vaulting' to screen inhibitors targeting kinases in their non-native state, demonstrating its effectiveness with the inhibitor FINDY (1) against DYRK1A.

This study shows that iSN40, a CpG-ODN, inhibits osteoclast formation via TLR9-dependent mechanisms and may be a therapeutic for osteoporosis.

This paper develops a 12-base myogenetic oligodeoxynucleotide that maintains the myogenic activity of a longer sequence while improving drug efficacy and synthesis cost.