NeurosciencebioRxivPreprint
Acid sphingomyelinase inhibition restores RPE homeostasis and photoreceptor function in preclinical Stargardt macular degeneration models
Colin J. Germer, Sydney Williams, Valencia Fernandes…·Aparna Lakkaraju
This study shows that inhibiting acid sphingomyelinase (ASM) restores RPE function and photoreceptor health in Stargardt disease models by reducing ceramide accumulation and improving EV biogenesis.
DOI 10.64898/2026.02.20.706984