Fangqing Zhao

The paper shows that strong TCR signals from foreign antigens destabilize Tregs, converting them into effector-like cells, while self-antigens preserve stability, revealing a mechanism for balancing immunity and tolerance.

CIRI-hub provides a webserver for integrated analysis and visualization of circular RNAs in cancer, offering access to 2187 tumor and 680 normal RNA-seq libraries across 33 tissue types.

The paper benchmarks 16 circRNA detection tools across three human cell types, finding large differences in sensitivity but consistent precision, and recommends tool combinations for improved detection.

This study profiles the vaginal microbiome of Chinese women during pregnancy and 6 weeks postpartum, identifying variations linked to medical history and pregnancy outcomes.

The paper analyzes the virulome across different body sites and diseases, finding higher VF diversity in the oral cavity and disease-specific VF abundance.